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  3. Effect Of Preoperative Frailty On Postoperative Infectious Complications And Prognosis In Patients With Colorectal Cancer: A Propensity Score Matching Study.
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Effect Of Preoperative Frailty On Postoperative Infectious Complications And Prognosis In Patients With Colorectal Cancer: A Propensity Score Matching Study.

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Effect of preoperative frailty on postoperative infectious complications and prognosis in patients with colorectal

Huipin Zhang1,2, Hailin Zhang2, Wei Wang1

  • 1Department of Nursing, The First People's Hospital of Changzhou and the 3rd Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, Jiangsu, 213000, China.

World Journal of Surgical Oncology
|June 11, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Preoperative frailty significantly increases the risk of intra-abdominal infections after colorectal cancer (CRC) surgery. Early frailty assessment and prehabilitation are crucial for managing CRC patients and preventing complications.

Keywords:
Adverse outcomesColorectal cancerComplicationsFrailtyIntra-abdominal infectionPropensity score matching

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Area of Science:

  • Surgical Oncology
  • Geriatric Medicine
  • Infectious Disease Epidemiology

Background:

  • Limited research exists on preoperative frailty's impact on infectious complications in colorectal cancer (CRC) patients.
  • Frailty assessment is crucial for predicting postoperative outcomes in surgical patients.

Purpose of the Study:

  • To investigate the effect of preoperative frailty on postoperative infectious complications in CRC patients.
  • To evaluate the association between frailty and prognosis using propensity score matching (PSM).

Main Methods:

  • A prospective observational cohort study of 245 CRC surgery patients.
  • Propensity score matching (PSM) was used to create matched frail and non-frail groups (75 pairs).
  • Infectious complications, ICU admission, mortality, length of stay, and costs were compared.

Main Results:

  • The frail group had a significantly higher incidence of intra-abdominal infections (10.7% vs. 1.3%, P<0.05).
  • Preoperative frailty was an independent risk factor for intra-abdominal infection (OR=12.014, P=0.027).
  • No significant differences were found in ICU admission, mortality, length of stay, or costs.

Conclusions:

  • Preoperative frailty is a significant risk factor for postoperative intra-abdominal infections in CRC surgery patients.
  • Early frailty assessment in CRC patients is recommended.
  • Targeted prehabilitation interventions should be considered for frail CRC patients.