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Updated: Jun 24, 2025

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SAAM II: A general mathematical modeling rapid prototyping environment.

Simone Perazzolo1,2

  • 1Nanomath LLC, Spokane, Washington, USA.

CPT: Pharmacometrics & Systems Pharmacology
|June 12, 2024
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Summary

Simulation Analysis and Modeling II (SAAM II) software offers intuitive compartmental modeling for life sciences, including pharmacokinetics and pharmacodynamics. This updated tutorial showcases its application in contemporary challenges like CAR-T-cell therapy and viral dynamics.

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Area of Science:

  • Life Sciences
  • Mathematical Modeling
  • Computational Biology

Background:

  • Simulation Analysis and Modeling II (SAAM II) is a graphical software for compartmental modeling.
  • It is widely used in pharmacokinetics (PK), pharmacodynamics (PD), metabolism, and tracer modeling.
  • The software allows users to build, solve, and fit models without coding, aiding education and rapid prototyping.

Purpose of the Study:

  • To demonstrate the updated applicability of SAAM II to current life sciences challenges.
  • To review SAAM II's features and present contemporary case studies.
  • To highlight SAAM II's utility for rapid model selection and prototyping.

Main Methods:

  • Review of SAAM II features and algorithms.
  • Application of SAAM II to four contemporary case studies: target-mediated PK/PD, CAR-T-cell therapy, viral dynamics, and epidemiological transmission models.
  • Utilizing SAAM II's capabilities for ordinary differential equations, forcing functions, Bayesian regression, identifiability, and sensitivity analyses.

Main Results:

  • SAAM II effectively handles complex kinetic analysis and PK/PD problems.
  • The software facilitates the creation of sophisticated mathematical models for diverse life science applications.
  • Case studies demonstrate SAAM II's suitability for rapid model development and analysis.

Conclusions:

  • SAAM II remains a valuable tool for compartmental modeling in life sciences.
  • Its updated features and applications address contemporary research needs.
  • The software provides an efficient interface for model prototyping and analysis, supporting both experts and non-modelers.