Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alzheimer's disease.

J P Blass

    Disease-A-Month : DM
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Alzheimer's disease is a common cause of dementia and death, characterized by cognitive decline and specific brain changes. Research is ongoing to understand its causes and develop effective treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A reproducible procedure for primary culture and subsequent maintenance of multiple lines of human skin fibroblasts.

    Age·2013
    Same author

    Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions?

    Age·2013
    Same author

    Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients.

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2010
    Same author

    Intensive nutritional supplements can improve outcomes in stroke rehabilitation.

    Neurology·2008
    Same author

    Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson's disease.

    Neurochemistry international·2003
    Same author

    Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?

    Journal of molecular neuroscience : MN·2002

    Area of Science:

    • Neurobiology
    • Gerontology
    • Neurology

    Background:

    • Alzheimer's disease (AD) is a leading cause of dementia and a significant cause of mortality.
    • It is recognized as a distinct age-related disease, not merely accelerated aging.
    • AD is characterized by insidious cognitive and behavioral impairments progressing over years.

    Purpose of the Study:

    • To provide a comprehensive overview of Alzheimer's disease.
    • To discuss current understanding of its clinical and neurobiological aspects.
    • To highlight diagnostic criteria and management strategies.

    Main Methods:

    • Review of clinical and neuropathological features of Alzheimer's disease.
    • Discussion of diagnostic criteria and current care approaches.

    Related Experiment Videos

  • Emphasis on ongoing clinical and basic research efforts.

    • Main Results:

    • Classic pathological hallmarks include Alzheimer plaques and neurofibrillary tangles.
    • Functional disability correlates with the location and extent of brain damage.
    • The underlying mechanisms of neuronal cell death remain unknown.

    Conclusions:

    • Diagnosis relies on identifying dementia compatible with AD, excluding other causes.
    • Current care is symptomatic, focusing on managing illness and maximizing function.
    • Specific treatments are under active investigation, with research accelerating.