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Exploring the Shared Genetic Architecture Between Obstructive Sleep Apnea and Body Mass Index
Peng Zhou1,2, Ling Li3, Zehua Lin1,2
1Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Nature and Science of Sleep
|June 12, 2024
Summary
Obstructive sleep apnea (OSA) and body mass index (BMI) share significant genetic links. This study reveals a strong genetic correlation and bidirectional causality between OSA and BMI, highlighting shared genetic underpinnings.
Area of Science:
- Genetics
- Sleep Medicine
- Metabolic Disorders
Background:
- Obstructive sleep apnea (OSA) and high body mass index (BMI) frequently co-occur.
- The underlying genetic factors contributing to this comorbidity are not well understood.
Purpose of the Study:
- To investigate the shared genetic architecture between OSA and BMI.
- To explore genetic overlaps and causal relationships between these two conditions.
Main Methods:
- Genome-wide association study (GWAS) summary statistics for OSA and BMI were analyzed.
- Comprehensive genome-wide cross-trait analysis was performed, including genetic correlation and Mendelian randomization.
- Pleiotropic loci and comorbid genes were identified.
Main Results:
- A significant positive global genetic correlation (r_g = 0.52, P < 2.85e-122) was found between OSA and BMI.
- Bidirectional causal associations were confirmed.
- 151 pleiotropic single-nucleotide polymorphisms (SNPs) and 134 expression-tissue pairs impacting both conditions were identified, particularly in 12 brain regions.
Conclusions:
- There is a substantial shared genetic architecture between OSA and BMI.
- These findings provide novel insights into the biological mechanisms underlying the comorbidity of OSA and obesity.
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