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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Updated: Jun 24, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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[Hyperinflammatory immune response syndrome PIMS-TS].

Magdalena Müller-Groen1, Gian Flury2

  • 1Departement ANIR, Institut für Anästhesiologie, Kantonsspital Graubünden, Chur.

Praxis
|June 12, 2024
PubMed
Summary
This summary is machine-generated.

Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a rare condition in children following COVID-19. Early intensive care and methylprednisolone treatment lead to low mortality and long-term issues.

Keywords:
PIMS-TS (Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2), MIS-C (Multisystem Inflammatory Syndrome in Children), COVID-19

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Area of Science:

  • Pediatric immunology
  • Infectious disease epidemiology

Background:

  • Pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a rare hyperinflammatory condition.
  • It typically manifests 2-6 weeks post-SARS-CoV-2 infection, primarily affecting schoolchildren.
  • Common symptoms include fever, gastrointestinal issues, cardiovascular dysfunction, and neurological signs.

Purpose of the Study:

  • To summarize the clinical presentation and management of PIMS-TS.
  • To highlight the importance of early diagnosis and intervention.

Main Methods:

  • Review of clinical signs and diagnostic criteria for PIMS-TS.
  • Analysis of treatment protocols, including intensive care and methylprednisolone administration.

Main Results:

  • PIMS-TS presents with diverse symptoms affecting multiple organ systems.
  • Diagnostic criteria can vary among different authors.
  • Intensive care with circulatory support and methylprednisolone is an effective treatment.

Conclusions:

  • PIMS-TS requires prompt recognition and management.
  • Effective treatment strategies contribute to favorable patient outcomes with low mortality and long-term consequences.