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Structural changes in eloquent cortex secondary to glioma in sensorimotor area
Yuhao Guo1,2, Hongbo Bao2,3, Zhishuo Wei4
1Department of Molecular Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
Human Brain Mapping
|June 12, 2024
Summary
Brain structural reorganization occurs in glioma patients, especially in sensorimotor areas. Impaired strength correlates with gray matter volume changes in specific brain regions, indicating neuroplasticity.
Area of Science:
- Neuroscience
- Neuroimaging
- Brain anatomy
Background:
- Gliomas can cause structural brain changes.
- Sensorimotor cortex function is crucial for movement.
- Understanding brain reorganization is key for patient recovery.
Purpose of the Study:
- Investigate sensorimotor cortex structural reorganization in glioma patients.
- Differentiate brain changes between patients with impaired and unimpaired strength.
- Identify specific brain regions affected by gliomas.
Main Methods:
- Voxel-based morphometry (VBM) and region of interest (ROI) analysis.
- Comparison of gray matter volumes (GMV) in sensorimotor areas.
- Analysis included contralesional primary motor/sensory gyri, premotor cortex, supplementary motor area (SMA), and medial Brodmann area 8 (BA8).
Main Results:
- Increased right medial BA8 volume in impaired right hemisphere glioma patients vs. unimpaired and healthy controls (HCs).
- Enlarged contralateral SMA in impaired left hemisphere glioma patients vs. unimpaired and HCs.
- Contralateral gray matter expansion in premotor and motor/sensory cortices observed.
- Negative correlation between hand strength (MRC score) and contralateral SMA/medial BA8 volumes.
Conclusions:
- Consistent structural reorganization in the sensorimotor cortex of glioma patients.
- Evidence of adaptive neuroplastic responses to glioma presence.
- Findings offer insights for neurosurgical planning and rehabilitation strategies.
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