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Physiochemically and Genetically Engineered Bacteria: Instructive Design Principles and Diverse Applications.

Xia Lin1, Rong Jiao1, Haowen Cui1

  • 1Central Laboratory and Department of Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Second Section, First Ring Road, Chengdu, Sichuan, 610072, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
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Summary
This summary is machine-generated.

Rationally-engineered bacteria, using physiochemical or genetic methods, show promise as novel therapeutics for diseases beyond cancer. This review details their design, applications, and clinical translation challenges.

Keywords:
bacterial derivativesdesign principlesdiverse applicationsgenetically‐engineered bacteriaphysiochemically‐engineered bacteria

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Area of Science:

  • Microbiology
  • Biotechnology
  • Nanotechnology

Background:

  • Engineered bacteria leverage advances in physiochemical and bioengineering for therapeutic applications.
  • These bacteria are designed using genetic or physiochemical technologies, often combined with nanotechnology.
  • Current research lacks comprehensive reviews on both physiochemically- and genetically-engineered bacteria and their derivatives.

Purpose of the Study:

  • To review the applications of physiochemically- and genetically-engineered bacteria and their derivatives.
  • To discuss design principles, engineering methods, and functions for various diseases beyond cancer.
  • To highlight strategies for developing in vivo biotherapeutic agents and their disease-repressing mechanisms.

Main Methods:

  • Classification and discussion of breakthroughs in engineered bacteria.
  • Emphasis on specific design principles and engineering methods for different applications.
  • Analysis of combined strategies for in vivo biotherapeutic agent development.

Main Results:

  • Engineered bacteria demonstrate significant roles in tumor lysis, immune regulation, and metabolic pathway influence.
  • The review covers applications beyond cancer, detailing specific design principles and engineering methods.
  • Strategies for developing engineered bacteria as in vivo biotherapeutics are elucidated.

Conclusions:

  • Physiochemically- and genetically-engineered bacteria represent a promising frontier in disease treatment.
  • Further research into their design, application, and clinical translation is warranted.
  • This review provides a comprehensive overview to guide future research in the field.