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The dynamic duo: cryo-EM teams up with machine learning to visualize biomolecules in motion

Beatrice Bowlby1

  • 1Expert Publishing Science Ltd, Unitec House, 2 Albert Place, London, N3 1QB, UK.

Biotechniques
|June 12, 2024
PubMed
Abstract

Keywords:
3DFlexbiomoleculescryo-EMmachine learning

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Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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