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Lensless Fluorescent Microscopy on a Chip

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Development of low-cost, compact chiroptical imaging systems.

Matthew D Ward^1,2, Ronan Docherty³, Louis Minion^3,4,5

¹Department of Physics, Imperial College London, South Kensington Campus, Prince Consort Road, London SW7 2AZ, UK.

|June 12, 2024

Summary

We developed low-cost, portable circular dichroism imaging systems using Fresnel rhombs. These systems enable rapid identification of optimal thermal processing conditions for chiral solid-state films.

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Area of Science:

Chiroptical spectroscopy
Materials science
Optical physics

Background:

Circular dichroism (CD) spectroscopy is crucial for analyzing chiral materials.
Commercial CD spectrometers are expensive, bulky, and lack environmental control.
There is a need for accessible and portable CD imaging systems.

Purpose of the Study:

To develop novel, low-cost, and portable circular dichroism imaging systems.
To enable spatial mapping of CD in chiral solid-state films.
To facilitate in situ analysis of thermal processing effects on CD.

Main Methods:

Utilized Fresnel rhombs as inexpensive broadband quarter-wave plates.
Developed bespoke open-source control software for the imaging systems.
Integrated systems with a temperature-controlled stage for in situ measurements.
Cross-compared results with a Diamond Light Source CD imaging system.

Main Results:

Demonstrated two novel, portable, and low-cost (<£2000) CD imaging systems.
Successfully mapped the circular dichroism of chiral solid-state films with high spatial resolution (100 μm).
Achieved high sensitivity (down to 250 mdeg) and good agreement with established systems.
Identified optimal thermal processing conditions for maximizing CD in situ.

Conclusions:

The developed CD imaging systems offer an affordable and portable alternative to commercial instruments.
These systems are effective for spatially mapping CD and optimizing material processing.
The technology advances the study of chiral materials, particularly in response to thermal stimuli.