Statistical optimization of guest uptake in crystalline sponges: grading structural outcomes

Investigation of the analyte soaking conditions on the crystalline sponge {[(ZnI₂)₃(tpt)₂·x(solvent)]_n} method using a statistical design of experiments model has provided fundamental insights into the influence of experimental variables. This approach focuses on a single analyte tested via 60 experiments (20 unique conditions) to identify the main effects for success and overall guest structure quality. This is employed as a basis for the development of a novel molecular structure grading system that enables the quantification of guest exchange quality.