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Updated: Jun 24, 2025
11:11
Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
9.2K
Mechanotransduction in the Vocal Fold Microenvironment: A Narrative Review.
Emily E Kimball1, Bernard Rousseau2
1Department of Hearing and Speech Sciences, Department of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN.
Summary
Vocal fold tissues constantly repair from injury. Mechanotransduction proteins may be key to maintaining vocal fold tissue health and homeostasis, offering new research avenues.
Area of Science:
- Biomedical Engineering
- Cellular Biology
- Otolaryngology
Background:
- Vocal fold tissues experience continuous injury and repair cycles.
- Personality and behavior influence vocal fold lesion risk, but do not fully explain development.
- Mechanotransduction proteins' role in vocal fold homeostasis is under-explored.
Purpose of the Study:
- To review current knowledge of mechanotransduction proteins.
- To explore their relevance to vocal fold tissue homeostasis.
- To apply findings to vocal fold physiology and pathophysiology.
Main Methods:
- Comprehensive literature review of mechanotransduction and vocal fold tissue.
- Searches included PubMed, Google Scholar, and peer-reviewed sources.
- Identified relevant literature using specific search terms and reference lists.
Main Results:
- Mechanically sensitive pathways are crucial for vocal fold tissue homeostasis.
- Mechanotransduction plays a significant role in managing constant mechanical forces.
- Understanding these pathways is vital for vocal fold health.
Conclusions:
- Mechanotransduction is critical for maintaining vocal fold tissue homeostasis.
- Mechanically sensitive molecular pathways are integral to vocal fold function.
- Targeting mechanotransduction is recommended for future vocal fold research.
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