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Closed-loop oxygen control for critically ill patients--A systematic review and meta-analysis
Caroline Gomes Mól1, Aléxia Gabriela da Silva Vieira1, Bianca Maria Schneider Pereira Garcia1
1Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Closed-loop oxygen systems improve oxygen saturation control in critically ill patients. These systems may also reduce healthcare professional workload and time spent with hypoxemia.
Area of Science:
- Critical care medicine
- Biomedical engineering
- Respiratory therapy
Background:
- The effectiveness and safety of closed-loop oxygen control systems in critically ill patients are not well-established.
- Manual oxygen titration methods present challenges in optimizing patient oxygenation.
Purpose of the Study:
- To systematically review and meta-analyze the impact of closed-loop oxygen systems compared to manual titration in critically ill patients.
- To evaluate effectiveness, efficacy, healthcare professional workload, and safety outcomes.
Main Methods:
- Systematic review and meta-analysis of randomized clinical trials.
- Searched multiple databases (MEDLINE, EMBASE, etc.) up to June 2023.
- Analyzed data using Review Manager software, focusing on time within SpO2 targets and secondary outcomes.
Main Results:
- Closed-loop systems increased time within the SpO2 target by 25.47% (moderate certainty).
- Potential reduction in hypoxemia duration (MD -0.98; low certainty).
- Significant reduction in healthcare professional workload (MD -4.94; low certainty).
Conclusions:
- Closed-loop oxygen control systems enhance time spent within target oxygen saturation levels.
- These systems show promise in reducing healthcare workload and potentially mitigating hypoxemia.
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