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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Analysis Of Lncrna-mirna-mrna Interactions Identified A Novel Biomarker Linc00657 To Improve Prognosis Prediction Of Papillary Thyroid Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Analysis Of Lncrna-mirna-mrna Interactions Identified A Novel Biomarker Linc00657 To Improve Prognosis Prediction Of Papillary Thyroid Carcinoma.

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Analysis of lncRNA-miRNA-mRNA interactions identified a novel biomarker LINC00657 to improve prognosis prediction of papillary thyroid carcinoma.

Shuang Li1, Mingli Wang2, Bing Liu3

  • 1Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Department of Endocrinology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

International Immunopharmacology
|June 12, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Long non-coding RNA LINC00657 is a novel prognostic biomarker for papillary thyroid cancer (PTC). Lower LINC00657 expression indicates better survival and immune cell infiltration, suggesting new therapeutic targets for PTC.

Keywords:
ImmunityLINC00657Papillary thyroid cancerceRNA network

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Papillary thyroid cancer (PTC) is the most prevalent thyroid malignancy.
  • Long non-coding RNAs (lncRNAs) play a role in cancer, but their function in PTC is not well understood.
  • Identifying novel biomarkers is crucial for understanding PTC's molecular mechanisms.

Purpose of the Study:

  • To identify novel long non-coding RNA (lncRNA) biomarkers for papillary thyroid cancer (PTC).
  • To investigate the prognostic value and immune-related functions of identified lncRNAs in PTC.
  • To explore potential new therapeutic targets for PTC.

Main Methods:

  • Constructed a comprehensive lncRNA-miRNA-mRNA network based on the competitive endogenous RNA (ceRNA) theory using The Cancer Genome Atlas (TCGA) data.
  • Performed survival analysis to assess the prognostic power of lncRNAs in PTC patients.
  • Examined the association between lncRNA expression and immune-related functions and molecular pathways.

    • Main Results:

    • Identified LINC00657 as a novel prognostic biomarker for PTC.
    • Found that low LINC00657 expression is significantly associated with better patient survival outcomes.
    • Demonstrated LINC00657's association with CD8+ T cell and macrophage infiltration, immune checkpoint molecules, and immune metagenes.
    • Observed correlations between high LINC00657 expression and cancer-related signaling pathways and BRAF mutations.

    Conclusions:

    • LINC00657 serves as an immune-related biomarker for improving prognosis prediction in PTC.
    • This study offers a potential new clinical treatment target for PTC.
    • Provides novel insights into the functional roles of lncRNAs in PTC development and progression.