Related Experiment Video
Updated: Jun 24, 2025
07:51
The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
Published on: November 4, 2010
21.9K
Anticoagulants Are a Risk Factor for Delayed Bleeding after Colorectal Endoscopic Submucosal Dissection: A HASID
Seong-Jung Kim1, Jun Lee1, Hyo-Yeop Song2
1Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, Republic of Korea.
Digestion
|June 12, 2024
Summary
Anticoagulant use increases the risk of delayed bleeding after colorectal endoscopic submucosal dissection (ESD). Careful monitoring is essential for patients undergoing colorectal ESD while on anticoagulants.
Area of Science:
- Gastroenterology
- Endoscopy
- Hepatology
Background:
- Delayed bleeding is a significant complication following colorectal endoscopic submucosal dissection (ESD).
- The role of anticoagulants as risk factors for this complication remains uncertain.
Purpose of the Study:
- To investigate the risk factors for delayed bleeding after colorectal ESD.
- Specifically evaluate the impact of anticoagulant use on delayed bleeding incidence.
Main Methods:
- Retrospective analysis of 1,708 patients undergoing colorectal ESD from 2015-2020.
- Identification of risk factors, focusing on antithrombotic agents, antiplatelet agents, and anticoagulants.
Main Results:
- Delayed bleeding occurred in 2.3% of patients.
- Antithrombotic agents (OR 6.16), antiplatelet agents (OR 4.61), and anticoagulants (OR 8.29) were significant risk factors.
- Anticoagulant use was associated with a higher delayed bleeding rate (12.5% vs. 1.6%) when antiplatelet agents were excluded.
Conclusions:
- Anticoagulant use is a significant risk factor for delayed bleeding post-colorectal ESD.
- The type of anticoagulant (direct oral anticoagulants vs. warfarin) did not influence the risk.
- Patients on anticoagulants require vigilant observation and management for delayed bleeding after colorectal ESD.
Related Concept Videos
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
675
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
675
01:25Endoscopic Procedures II: Colonoscopy
82
The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
82
01:24Disorders of Hemostasis
837
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
837
01:28Esophageal Varices-II: Clinical Features and Management
58
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
58
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
72
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
72