Circulating asprosin concentrations in individuals with new-onset type 2 diabetes and prediabetes
View abstract on PubMed
Summary
This summary is machine-generated.Elevated serum asprosin levels are associated with type 2 diabetes mellitus (T2DM) and prediabetes. This finding suggests asprosin may indicate early glucose homeostasis disturbances.
Area Of Science
- Endocrinology
- Metabolic Disorders
- Diabetes Research
Background
- Mixed findings exist regarding asprosin's role in type 2 diabetes mellitus (T2DM).
- Limited research has explored asprosin's impact on prediabetic conditions, such as impaired glucose regulation (IGR).
Purpose Of The Study
- To investigate the association between serum asprosin levels and the presence of T2DM.
- To evaluate asprosin's potential as a biomarker for early glucose metabolism abnormalities, including IGR and T2DM.
Main Methods
- An observational study involving 252 adults categorized into normal glucose tolerance (NGT), IGR, and T2DM groups.
- Serum asprosin levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- Participants underwent assessments of anthropometric and biochemical markers.
Main Results
- Serum asprosin levels were significantly elevated in individuals with newly diagnosed T2DM and slightly increased in the IGR group compared to the NGT group.
- A progressive increase in IGR + T2DM patient proportions was observed across asprosin quartiles, indicating a potential risk association.
- Receiver Operating Characteristic (ROC) curve analysis showed an Area Under Curve (AUC) of 0.853 for asprosin in identifying IGR + T2DM, with a threshold of 4.95 ng/ml.
Conclusions
- Individuals with prediabetes (IGR) and newly diagnosed T2DM exhibit elevated serum asprosin levels.
- Increased asprosin concentrations are linked to early disruptions in glucose homeostasis.
- Asprosin may serve as a potential biomarker for identifying individuals at risk for or in the early stages of T2DM.
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