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Adjunctive Statin Therapy in Patients with Covid-19: A Systematic Review and Meta-Analysis of Randomized Controlled

Cynthia Florêncio de Mesquita1, André Rivera2, Beatriz Araújo2

  • 1Department of Medicine, Federal University of Pernambuco, Recife, Brazil.

The American Journal of Medicine
|June 12, 2024
PubMed

Insights

Adjunctive statin therapy in hospitalized patients with coronavirus disease 2019 (COVID-19) significantly lowers mortality and disease severity. This meta-analysis of randomized controlled trials confirms statins

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • The role of statin therapy as an adjunct treatment for hospitalized COVID-19 patients remains unclear.
  • Evaluating the efficacy and safety of statins in this population is crucial for clinical decision-making.

Approach:

  • A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted.
  • Searches included Medline, Embase, Cochrane, and ClinicalTrials.gov up to April 2024.
  • Data from 7 RCTs involving 4,262 patients were pooled using random-effects models.

Key Points:

  • Statin use significantly reduced the case-fatality rate (RR 0.88; 95% CI 0.80-0.98) and WHO scale score at 14 days (MD -0.27; 95% CI -0.54 to -0.01).
  • Time-to-event analysis showed similar mortality reduction (HR 0.86; 95% CI 0.75-0.99).
  • No significant differences were observed in hospital stay duration or key inflammatory markers.

Conclusions:

  • Adjunctive statin therapy demonstrates significant benefits in reducing mortality and disease severity in hospitalized COVID-19 patients.
  • Statins represent a potentially valuable therapeutic option for this patient group.
Abstract

Keywords:
Case-fatality rateCoronavirusCovid-19Statins

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