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Decreased Beta Power and OFC-STN Phase Synchronization during Reactive Stopping in Freely Behaving Rats.

Jordi Ter Horst^1,2, Morgane Boillot^3,2, Michael X Cohen^3,2

¹Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen 6525 EN, The Netherlands jordi.terhorst@radboudumc.nl.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|June 12, 2024

Summary

This summary is machine-generated.

Researchers studied reactive stopping in rats, finding that the orbitofrontal cortex (OFC) and subthalamic nucleus (STN) show reduced beta-band activity during successful action stopping. This highlights their role in the hyperdirect pathway for motor control.

Keywords:

beta power orbitofrontal cortex phase synchronization reactive stopping stop-signal task subthalamic nucleus

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Area of Science:

Neuroscience
Systems Neuroscience
Behavioral Neuroscience

Background:

Reactive stopping, crucial for adapting behavior, is primarily studied in humans.
The hyperdirect pathway, involving the orbitofrontal cortex (OFC) and subthalamic nucleus (STN), is hypothesized to mediate reactive stopping.
Direct investigation of OFC and STN roles in reactive stopping using animal models is lacking.

Purpose of the Study:

To directly investigate the contribution and interaction of the OFC and STN in reactive stopping.
To quantify neural oscillatory activity and interareal synchronization between OFC and STN during a stop-signal task in rats.

Main Methods:

Dual-area, multielectrode recordings were performed in male rats during a stop-signal task.
Rats were trained to initiate movements to a go-signal and to stop upon presentation of a stop-signal.
Field potential reductions in the beta frequency range (12-30 Hz) and phase synchronization between OFC and STN were analyzed.

Main Results:

Both OFC and STN exhibited transient (∼200 ms) reductions in beta frequency field potentials during reactive stopping.
These reductions occurred specifically when the stop-signal was received after action initiation.
A transient attenuation of beta-band synchronization between the OFC and STN was observed during reactive stopping.

Conclusions:

The OFC and STN show specific, transient neural oscillatory changes during reactive stopping.
These findings provide direct evidence for the involvement of OFC-STN interactions within the hyperdirect pathway in reactive stopping.
This study quantifies neural activity and synchronization in these regions during a critical motor control process.