The triglyceride glucose index was nonlinearly associated with all-cause mortality in diabetic patients
Beibei Gao1, Chao Yang2, Guomin Wu3
1Department of Cardiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310000, China; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310000, China.
Background And Aim:
The TyG index has been linked with cardiometabolic diseases. Our study aimed to investigate the specific relationship between the triglyceride and glucose index (TyG) and both all-cause and cardiovascular mortality in diabetic patients.
Methods And Results:
We enrolled 3120 participants with diabetes from the National Health and Nutrition Examination Survey. The TyG index was calculated using the formula ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Hazard ratios (HRs) of TyG associated with mortality risk were assessed using Cox proportional hazard regression models. Over a follow-up period of 10.8 thousand person-years, we observed 768 all-cause deaths and 155 cardiovascular deaths. Compared to the reference quartile, the multivariate-adjusted hazard ratios and 95% confidence intervals for all-cause mortality were 1.02 (1.01-1.05; p = 0.008) in the fourth quartile. Dose-response analysis revealed a non-linear association. However, no significant associations were found between the TyG index and cardiovascular mortality.
Conclusions:
The TyG index exhibited a non-linear association with the risk of all-cause mortality in diabetic patients.
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