Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.5K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.5K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Lactate Dehydrogenase A Is Associated With Elevated Fdg Metabolism, Radioiodine Non-avidity, And Poor Prognosis In Differentiated Thyroid Cancer

Lactate Dehydrogenase A is Associated with Elevated FDG Metabolism, Radioiodine Non-avidity, and Poor Prognosis in Differentiated Thyroid Cancer

Tian Tian1, Hongyuan Dai1, Mengni Zhang2

  • 1Department of Nuclear Medicine, West China Hospital, Sichuan University, No 37. Guoxue Alley 610041, Chengdu, China.

Academic Radiology
|June 12, 2024

Related Experiment Videos

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

517
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

583

View abstract on PubMed

Summary
This summary is machine-generated.

Lactate dehydrogenase A (LDHA) expression is linked to increased glucose metabolism and reduced radioiodine avidity in differentiated thyroid cancer (DTC). Higher LDHA and 18F-FDG PET/CT markers predict shorter progression times.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Biochemistry

Background:

  • The role of lactate dehydrogenase A (LDHA) in differentiated thyroid cancer (DTC), particularly radioiodine-refractory DTC, requires clarification.
  • Understanding LDHA's impact on glycolysis and radioactive iodine (RAI) avidity is crucial for prognostic assessment.

Purpose of the Study:

  • To investigate the relationship between LDHA expression, glycolysis, and RAI avidity in DTC.
  • To evaluate the prognostic value of LDHA and metabolic parameters in DTC patients.

Main Methods:

  • Enrolled 69 DTC patients who underwent 18F-FDG PET/CT and surgery.
  • Assessed LDHA, glucose transporter (Glut) protein expression via immunohistochemistry.
  • Measured 18F-FDG PET/CT parameters (SUVmax, MTV, TLG) and determined lesion RAI avidity.
Keywords:
18 F-FDG PET/CTDifferentiated Thyroid CancerLactate Dehydrogenase APrognosis

Related Experiment Videos

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

517
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

11.1K
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
05:41

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

583

Main Results:

  • LDHA expression correlated with Glut3 and SUVmax.
  • Lower LDHA expression and SUVmax were observed in the RAI avidity group.
  • Elevated SUVmax, MTV, TLG, and LDHA expression were associated with shorter time to progression (TTP).

Conclusions:

  • Elevated LDHA correlates with increased glucose metabolism, decreased RAI avidity, and faster DTC progression.
  • 18F-FDG PET/CT serves as an effective "in vivo pathology" for predicting DTC prognosis.
  • Total lesion glycolysis (TLG) emerged as an independent prognostic factor for TTP.
Radioiodine avidity