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Allostatic Load As A Predictor Of Postoperative Complications In Patients With Breast Cancer.

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Allostatic Load As A Predictor Of Postoperative Complications In Patients With Breast Cancer.

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Allostatic load as a predictor of postoperative complications in patients with breast cancer.

J C Chen¹, Mohamed I Elsaid^2,3,4, Demond Handley^2,3

¹Division of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, OH, USA.

NPJ Breast Cancer

|June 12, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Cumulative stress, measured as allostatic load (AL), is linked to increased postoperative complications (POC) in breast cancer patients. Higher AL significantly elevates the risk of developing POC after surgery.

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Area of Science:

Oncology
Public Health
Biomedical Science

Background:

Allostatic load (AL) quantifies cumulative exposure to socioenvironmental stressors.
Understanding factors influencing postoperative complications (POC) is crucial for patient outcomes in breast cancer surgery.

Purpose of the Study:

To investigate the association between allostatic load (AL) and the occurrence of postoperative complications (POC) in breast cancer patients.

Main Methods:

Utilized data from the Ohio State Cancer registry for female breast cancer patients (Stage I-III) who underwent surgery (2012-2020).
Calculated a composite AL score using biomarkers from cardiovascular, metabolic, immune, and renal systems.
Employed univariable and multivariable regression analyses to assess the relationship between AL and POC within 30 days of surgery.

Main Results:

8.2% of 4459 patients experienced POC.
High AL was associated with a 29% increased odds of POC (aOR 1.29).
Each one-point increase in AL correlated with an 8% increase in POC odds (aOR 1.08).

Conclusions:

Increased allostatic load, reflecting cumulative stress exposure, is significantly associated with a higher likelihood of postoperative complications in breast cancer surgery patients.
These findings highlight the impact of socioenvironmental stressors on surgical outcomes and suggest potential targets for intervention.