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Oogenesis02:07

Oogenesis

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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
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  11. Oral Exposure To Bisphenol S Is Associated With Alterations In The Oviduct Proteome Of An Ovine Model, With Aggravated Effects In Overfed Females.
  1. Home
  3. Research Domains
  5. Biological Sciences
  7. Industrial Biotechnology
  9. Bioprocessing, Bioproduction And Bioproducts
  11. Oral Exposure To Bisphenol S Is Associated With Alterations In The Oviduct Proteome Of An Ovine Model, With Aggravated Effects In Overfed Females.

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Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
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Oral exposure to bisphenol S is associated with alterations in the oviduct proteome of an ovine model, with aggravated effects in overfed females.

Coline Mahé1, Marie-Emilie Lebachelier de la Riviere2, Olivier Lasserre3

  • 1INRAE, CNRS, Université de Tours, PRC, Nouzilly, 37380, France. coline.mahe@inrae.fr.

BMC Genomics
|June 12, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Bisphenol S (BPS) significantly alters oviduct fluid proteins, especially in overfed ewes, impacting reproductive health. This highlights concerns regarding BPS exposure and calls for stricter food industry regulations.

Keywords:
Bisphenol SDietMass spectrometryOviduct

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Area of Science:

  • Reproductive Biology
  • Environmental Toxicology
  • Proteomics

Background:

  • Bisphenol S (BPS) is a BPA substitute used in plastics.
  • BPS is a potential endocrine disruptor affecting mammalian fertilization and early embryo development.
  • The oviduct plays a critical role in reproductive processes.

Purpose of the Study:

  • To investigate the impact of dietary Bisphenol S (BPS) exposure on the oviduct fluid proteome.
  • To assess the combined effects of BPS and contrasting diets (overfed vs. underfed) on oviduct physiology.
  • To utilize an ovine model for studying BPS effects on reproductive health.

Main Methods:

  • Eighty adult cyclic ewes were divided into four groups: overfed (OF) and underfed (UF), with and without BPS exposure (50 µg/kg/day).
Ovine
Protein
Proteomic
Secretions
Sheep
  • Dietary interventions lasted for three months.
  • Oviduct fluid proteome was analyzed using nanoliquid chromatography coupled with tandem mass spectrometry (nanoLC-MS/MS).

    • Main Results:

    • A total of 1563 proteins were identified, with 848 quantified in the oviduct fluid.
    • Diet significantly influenced the proteome, and BPS exposure caused distinct protein profile changes, particularly in overfed ewes.
    • BPS had a more pronounced effect in overfed ewes (70 differentially abundant proteins) compared to underfed ewes (24 differentially abundant proteins).

    Conclusions:

    • Bisphenol S significantly impacts the oviduct proteome, with effects amplified by overfeeding.
    • These findings underscore the potential health risks associated with BPS exposure.
    • Increased regulation of BPS in the food industry is recommended.