Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spongy Bone01:09

Spongy Bone

4.3K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
4.3K
Compact Bone01:27

Compact Bone

11.4K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
11.4K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

3.4K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
3.4K
Bone Markings01:26

Bone Markings

5.3K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
5.3K
Bone Structure01:55

Bone Structure

48.1K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
48.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cartilage targeted grape skin-derived extracellular vesicles ameliorate osteoarthritis by attenuating chondrocyte senescence.

Journal of nanobiotechnology·2026
Same author

Failure modes and effects analysis of LINAC-based stereotactic arrhythmia radioablation categorized by segmental targets.

Radiation oncology (London, England)·2026
Same author

Aptamer-functionalized tetrahedral framework nucleic acid delivery of siBhlhe22 for repairing osteoporotic bone defects via dual modulation of PI3K-Akt signaling and purine metabolism.

Journal of nanobiotechnology·2026
Same author

Influence of <i>Vitex negundo</i> encroachment on soil aggregate stability and erosion resistance of grasslands in Northwest Liaoning.

Ying yong sheng tai xue bao = The journal of applied ecology·2026
Same author

Neuro-skeletal units and Smart Analgesia: reprogramming sensory neurons for fracture repair.

Military Medical Research·2026
Same author

Acupuncture-related Digital Joint Infection Managed With Staged Surgery And Oral Antibiotic Therapy.

Journal of visualized experiments : JoVE·2026
Same journal

A roadmap for medical large language models: a review of foundations, applications, and challenges.

Military Medical Research·2026
Same journal

The concept of neurogenic organ dysfunction is not new and should encompass all aspects of the underlying pathophysiological mechanisms.

Military Medical Research·2026
Same journal

A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation.

Military Medical Research·2026
Same journal

Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.

Military Medical Research·2026
Same journal

PM2.5 as a driver of human health disorders: insights from the regulated cell death pathways.

Military Medical Research·2026
Same journal

Crosstalk in the brain tumor microenvironment: mechanisms, therapeutic strategies, and clinical advances.

Military Medical Research·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2025

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.7K

Bone-organ axes: bidirectional crosstalk.

An-Fu Deng1,2, Fu-Xiao Wang1,2, Si-Cheng Wang1,2,3

  • 1Institute of Translational Medicine, Organoid Research Center, Shanghai University, Shanghai, 200444, China.

Military Medical Research
|June 12, 2024
PubMed
Summary
This summary is machine-generated.

Bone secretes osteokines to support organ function, while organs influence bone health. This review explores this bone-organ crosstalk, including extracellular vesicles, for disease insights and advanced in vitro models.

Keywords:
Bidirectional crosstalkBone-organ axesCytokinesExtracellular vesiclesHormonesMetabolitesOsteokines

More Related Videos

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

441
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

1.4K

Related Experiment Videos

Last Updated: Jun 24, 2025

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.7K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

441
Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling
06:51

Author Spotlight: PEGASOS Tissue Clearing Technique to Visualize Bone Remodeling

Published on: August 18, 2023

1.4K

Area of Science:

  • Endocrinology and Metabolism
  • Cell Biology
  • Biomedical Engineering

Background:

  • Bone provides structural support and secretes cytokines (osteokines) crucial for organ function and homeostasis.
  • A bidirectional crosstalk exists between bone and other organs, influencing bone development and systemic health.
  • This complex bone-organ axis interaction remains incompletely understood and lacks systematic review.

Purpose of the Study:

  • To elucidate the bidirectional communication between bone and organs, focusing on the role of osteokines.
  • To highlight the function of extracellular vesicles (EVs) in bone-organ axes.
  • To explore implications for developing advanced in vitro models like bone-on-chips and assembloids.

Main Methods:

  • Systematic review of existing literature on bone-organ crosstalk.
  • Analysis of the role of osteokines and extracellular vesicles in mediating these interactions.
  • Exploration of the physiological relevance of these interactions for disease mechanisms and therapeutic strategies.

Main Results:

  • Osteokines secreted by bone critically regulate organ function and systemic homeostasis.
  • Organs reciprocally influence bone remodeling and development through secreted factors.
  • Extracellular vesicles play a significant, previously underappreciated role in bone-organ communication.

Conclusions:

  • Understanding the bone-organ axis crosstalk, including osteokines and EVs, is vital for comprehending systemic diseases.
  • This knowledge is essential for designing physiologically relevant in vitro models for research and drug discovery.
  • The review provides a theoretical foundation for novel diagnostic and therapeutic approaches targeting the bone-organ axis.