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Cushing Syndrome Is Associated With a Higher Risk of Cancer-A Nationwide Cohort Study.

Wan-Chen Wu1, Jia-Ling Wu2, Tien-Shang Huang1

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100229, Taiwan.

The Journal of Clinical Endocrinology and Metabolism
|June 13, 2024
PubMed
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Patients with Cushing syndrome (CS) face a doubled risk of developing cancer. This study highlights the increased cancer incidence in individuals with CS, emphasizing the need for monitoring and preventative strategies.

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Area of Science:

  • Endocrinology
  • Oncology
  • Epidemiology

Background:

  • Cushing syndrome (CS) is linked to obesity and diabetes, known cancer risk factors.
  • The association between endogenous CS and cancer incidence remains unclear.

Purpose of the Study:

  • To determine if endogenous Cushing syndrome increases cancer risk.
  • Investigating the link between CS and overall cancer incidence.

Main Methods:

  • Nationwide cohort study using Taiwan's National Health Insurance data (2006-2017).
  • Identified 1246 patients with newly diagnosed endogenous CS and no prior malignancy.
  • Analyzed age- and sex-standardized cancer incidence rates and standardized incidence ratios (SIR).

Main Results:

  • Cancer incidence rate in CS patients was 7.77 per 1000 person-years.
  • A significantly higher cancer risk was observed, with a SIR of 2.08.
  • The most common cancers were liver, kidney, and lung.

Conclusions:

  • Endogenous Cushing syndrome is associated with a higher incidence of cancer.
  • Patients with CS exhibit an elevated risk for developing various cancers.