Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Digitalis and the autonomic nervous system.

A M Watanabe

    Journal of the American College of Cardiology
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Digitalis primarily affects the autonomic nervous system, especially the parasympathetic nerves at therapeutic doses. Toxic doses may increase sympathetic activity, potentially causing arrhythmias.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Real-time monitoring and kinetic parameter estimation of the affinity interaction of jArtinM and rArtinM with peroxidase glycoprotein by the electrogravimetric technique.

    Biosensors & bioelectronics·2010
    Same author

    Rhnull syndrome: identification of a novel mutation in RHce.

    Transfusion·2005
    Same author

    Genetic information, genomic technologies, and the future of drug discovery.

    JAMA·2001
    Same author

    Protein dephosphorylation rates in myocytes after isoproterenol withdrawal.

    Biochemical pharmacology·2000
    Same author

    Muscarinic-cholinoceptor mediated attenuation of phospholamban phosphorylation induced by inhibition of phosphodiesterase in ventricular cardiomyocytes: evidence against a cAMP-dependent effect.

    Molecular and cellular biochemistry·1998
    Same author

    Evidence for presence and hormonal regulation of protein phosphatase inhibitor-1 in ventricular cardiomyocyte.

    The American journal of physiology·1996

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Cardiology

    Background:

    • Digitalis exerts its effects by modulating the autonomic nervous system.
    • The autonomic nervous system comprises sympathetic and parasympathetic components.

    Purpose of the Study:

    • To elucidate the role of the autonomic nervous system in mediating Digitalis's pharmacodynamic actions.
    • To investigate the impact of Digitalis on both parasympathetic and sympathetic nerve activity.

    Main Methods:

    • The study focuses on the known physiological effects of Digitalis in animal and human subjects.
    • Analysis of electrophysiologic effects and arrhythmogenic potential related to Digitalis administration.

    Main Results:

    • Digitalis significantly alters parasympathetic nervous system properties at therapeutic concentrations.

    Related Experiment Videos

  • Sympathetic nerve activity stimulation may occur with toxic Digitalis concentrations, potentially contributing to arrhythmias.
  • Digitalis's autonomic effects are crucial for its overall pharmacodynamics in patients.

    • Conclusions:

    • Digitalis's primary actions are mediated through the autonomic nervous system, with distinct effects on parasympathetic and sympathetic activity.
    • Understanding these autonomic effects is key to managing Digitalis therapy and potential drug interactions.