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Updated: Jun 24, 2025

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Large area robotically assisted optical coherence tomography (LARA-OCT).

Simon Lotz1, Madita Göb1, Sven Böttger2,3

  • 1Institute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.

Biomedical Optics Express
|June 13, 2024
PubMed
Summary
This summary is machine-generated.

Large-area robotically assisted optical coherence tomography (LARA-OCT) enables imaging of large and curved surfaces. This system integrates a robotic arm and MHz-OCT for efficient, high-resolution scans without external tracking.

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Area of Science:

  • Biomedical Engineering
  • Optical Imaging
  • Robotics

Background:

  • Conventional optical coherence tomography (OCT) is limited to small, planar sample areas.
  • Imaging large or arbitrarily shaped surfaces, such as biological tissues, requires advanced scanning techniques.
  • Existing methods often necessitate complex external machine vision systems for tracking and registration.

Purpose of the Study:

  • To develop and demonstrate a large-area robotically assisted optical coherence tomography (LARA-OCT) system.
  • To enable high-resolution OCT imaging over extended and non-planar sample regions.
  • To integrate robotic control and OCT imaging for streamlined data acquisition.

Main Methods:

  • Utilized a seven-degree-of-freedom robotic arm coupled with a 3.3 MHz swept-source OCT.
  • Implemented a raster scanning strategy to cover arbitrary sample shapes by combining multiple fields of view (FOV).
  • Developed real-time probe-to-surface control using OCT image data for orthogonal alignment, eliminating the need for external machine vision.

Main Results:

  • Successfully demonstrated LARA-OCT for imaging large-area samples, including curved surfaces like skin.
  • Achieved efficient data acquisition, capturing 140 × 170 × 20 mm³ volume datasets in 2.5 minutes.
  • Eliminated the requirement for separate cameras, positioning, tracking, or navigation devices through integrated OCT-based tracking and stitching.

Conclusions:

  • LARA-OCT significantly expands the imaging area achievable with OCT, overcoming limitations of conventional systems.
  • The integrated approach simplifies the imaging workflow and reduces hardware complexity.
  • This technology is well-suited for high-resolution, large-volume imaging of diverse sample geometries.