GTDrift: a resource for exploring the interplay between genetic drift, genomic and transcriptomic characteristics in...

Area of Science:

• Evolutionary Biology
• Genomics
• Transcriptomics

Background:

• Understanding genetic drift is crucial for evolutionary studies.
• Comparative genomics and transcriptomics require integrated data resources.
• Existing resources may lack comprehensive genetic drift proxies and cross-species transcriptomic data.

Purpose of the Study:

• To introduce GTDrift, a novel data resource for exploring genomic and transcriptomic characteristics.
• To provide proxies for the intensity of genetic drift across a wide range of eukaryotic species.
• To facilitate comparative transcriptomics analyses and evolutionary studies.

Main Methods:

• Compiled data for 1506 eukaryotic species (1413 animals, 93 plants).
• Included effective population size proxies: life history traits (979 species) and dN/dS ratios (1324 species).
• Processed over 16,000 RNA-seq samples (491 species) for comparative transcriptomics, including splicing, expression, and depth, with orthology predictions.

Main Results:

• GTDrift integrates diverse genomic, transcriptomic, and population genetics data for 1506 species.
• Effective population size proxies (life history, dN/dS) are provided for extensive species coverage.
• Processed transcriptomic data and orthology predictions enable cross-species comparative analyses.

Conclusions:

• GTDrift serves as a valuable, comprehensive resource for evolutionary and population genetics research.
• The resource facilitates novel investigations into the relationship between genomic/transcriptomic features and genetic drift.
• Enables researchers to perform large-scale comparative analyses of splicing, gene expression, and evolutionary dynamics.