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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

356
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
356
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

324
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
324
Blood Transfusion01:15

Blood Transfusion

542
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
542
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Learning Curve Of Covid-19 And Organ Donation: Potential Missed Opportunities In The Covid Era.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Learning Curve Of Covid-19 And Organ Donation: Potential Missed Opportunities In The Covid Era.

Related Experiment Video

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

1.6K

The learning curve of COVID-19 and organ donation: Potential missed opportunities in the COVID era.

Jared R Zhang1, Muhammad Mujtaba2, Heidi Wagenhauser3

  • 1Department of Surgery, Division of Multiorgan Transplant and Hepatobiliary Surgery, The University of Texas Medical Branch, 301 University Blvd, Galveston TX 77550, USA.

Heliyon
|June 13, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Early COVID-19 policies wrongly excluded many organ donors. This study shows COVID-19 status significantly reduced organ donations, highlighting missed opportunities for transplants and the need for updated donor management protocols.

Keywords:
COVID-19Organ donationOrgan procurement organizationsPandemic impact on health services

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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

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Related Experiment Videos

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
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Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Area of Science:

  • Transplantation immunology
  • Infectious disease epidemiology
  • Public health policy

Background:

  • Early COVID-19 pandemic policies frequently disqualified organ donors based on infection status.
  • Limited evidence supported the exclusion of COVID-19 positive donors for non-lung transplants.
  • This study addresses the impact of donor COVID-19 status on organ availability.

Purpose of the Study:

  • To quantify the number of eligible organ donors lost due to COVID-19 status.
  • To assess the impact of donor COVID-19 positivity on organ procurement rates.
  • To identify missed organ donation opportunities during the early pandemic.

Main Methods:

  • Retrospective analysis of deceased donor referrals to an organ procurement organization (OPO).
Retrospective studies
Transplant outcomes
  • Categorization of referrals into All Referrals, Medically Ruled Out (MRO), and Procured Donors (PD).
  • Comparison of COVID-negative and COVID-positive donor cohorts using Chi-square tests and logistic regression.

    • Main Results:

    • Over 23% of 9478 referrals were COVID-positive.
    • COVID-positive referrals had significantly higher MRO rates (80.6%) and lower PD rates (0.2%) compared to COVID-negative referrals.
    • An estimated 103 organs were missed due to COVID-19 status disqualification.

    Conclusions:

    • Donor COVID-19 status significantly impacted organ donation rates, leading to substantial missed opportunities.
    • Revising donor management protocols based on evolving evidence can increase organ availability.
    • Optimizing organ donor selection criteria can improve national organ transplant capacity.