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Predictors of probable attention deficit hyperactivity disorder in elderly patients with mild cognitive impairment

Shiho Nagano1,2,3, Naoto Kamimura1,4, Satoko Sota1,3

  • 1Department of Neuropsychiatry, Kochi Medical School Kochi University Kochi Japan.

PCN Reports : Psychiatry and Clinical Neurosciences
|June 13, 2024
PubMed
Abstract

Insights

A quarter of elderly patients with mild cognitive impairment (MCI) also showed signs of probable attention deficit hyperactivity disorder (ADHD). Male sex and current hyperactivity were key predictors for identifying ADHD in MCI patients.

Area of Science:

  • Gerontology
  • Neuropsychology
  • Psychiatry

Background:

  • Attention deficit hyperactivity disorder (ADHD) symptoms can persist into old age, often overlapping with mild cognitive impairment (MCI).
  • The prevalence and identifying factors of probable ADHD in MCI patients remain unclear.

Purpose of the Study:

  • To estimate the proportion of MCI patients with probable ADHD.
  • To identify factors that predict probable ADHD in individuals with MCI.

Main Methods:

  • Recruited 36 elderly patients meeting MCI criteria.
  • Classified patients into MCI/ADHD (+) and MCI/ADHD (-) groups using the Wender Utah Rating Scale.
  • Compared autism features, inattention, hyperactivity, IQ, and demographics; utilized logistic regression for factor identification.

Main Results:

  • Nine (25.0%) patients were classified as MCI/ADHD (+).
  • The MCI/ADHD (+) group had a higher proportion of males, younger clinic visitors, more educated individuals, and those with autism spectrum disorder tendencies.
  • Male sex and current hyperactivity emerged as significant predictors of probable ADHD in MCI patients.

Conclusions:

  • Approximately 25% of MCI patients exhibited probable ADHD.
  • Male sex and the presence of hyperactivity during MCI diagnosis may aid in predicting probable ADHD.
  • Findings require validation through larger, longitudinal studies due to the small sample size and single-center nature.
Keywords:
attention deficit hyperactivity disordermemory clinicmild cognitive impairmentpredictor

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