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Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

Updated: Jun 24, 2025

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

Published on: January 10, 2025

MicroEXPERT: Microbiome profiling platform with cross-study metagenome-wide association analysis functionality.

Pengshuo Yang^1,2, Jialiang Yang^3,4,5, Haixia Long⁶

¹Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center of AI Biology, Department of Bioinformatics and Systems Biology College of Life Science and Technology, Huazhong University of Science and Technology Wuhan Hubei China.

|June 13, 2024

Summary

This summary is machine-generated.

MicroEXPERT is a five-module platform for analyzing microbial community data. It facilitates data management, processing, metagenome-wide association studies (MWAS), sequence searching, and result visualization for comprehensive microbiome insights.

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Last Updated: Jun 24, 2025

A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

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Published on: January 10, 2025

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A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

Published on: July 1, 2020

Area of Science:

Microbiology
Bioinformatics
Computational Biology

Background:

Microbiome research generates vast datasets requiring sophisticated analytical tools.
Integrating data management, processing, and analysis is crucial for efficient microbiome studies.

Purpose of the Study:

To introduce the MicroEXPERT platform, a comprehensive system for microbiome data analysis.
To outline the functionalities of the five integrated modules within the MicroEXPERT platform.

Main Methods:

Data management: Guided workflow for uploading raw data and metadata.
Data processing: Generation of taxonomical and functional profiles.
Metagenome-wide association studies (MWAS): Biomarker analysis, PCA, network analysis, and classification.
Data search: Nucleotide sequence querying against the MicroEXPERT database.
Data visualization: Tools for presenting metagenomic analysis results.

Main Results:

The platform provides a unified environment for the entire microbiome analysis pipeline.
Users can perform complex analyses, from data input to result interpretation.
The integrated approach enhances the efficiency and accessibility of microbiome research.

Conclusions:

MicroEXPERT offers a robust framework for microbiome data analysis.
The platform supports diverse analytical approaches, including MWAS and sequence searching.
It empowers researchers with tools for comprehensive microbiome investigation.