A high-salt diet induces synaptic loss and memory impairment via gut microbiota and butyrate in mice
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Updated: Jun 24, 2025
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
Chao Lei1,2, Cong Liu2, Yuling Peng2
1Department of Anorectal Surgery, Affiliated Dongguan Hospital Southern Medical University (Dongguan People's Hospital) Dongguan China.
Abstract:
High-salt diet (HSD)-fed mice display cognitive impairment and lower synaptic proteins via changed gut microbiota composition and short-chain fatty acids production. Gut microbiota from HSD-fed mice impairs memory and synapse in normal salt diet-fed mice. Butyrate treatment partially reverses memory impairment in HSD-fed mice. Above all, this study indicates the important role of the gut microbiome and butyrate production in synaptic loss and memory impairment.
