JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Do HPV 16 positive/ASC-H cervical cancer screening results predict CIN 2+ better than other high-risk HPV subtypes?

  • 0Clinic of Gynecologic Oncology, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey.
Journal of the Turkish German Gynecological Association +

|

June 13, 2024

|

June 13, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High-risk human papillomavirus (HPV) positivity, particularly HPV 16, is significantly correlated with CIN 2+ lesions in patients with ASC-H cytology. This finding highlights the importance of HPV testing in managing ASC-H results for early detection of high-grade dysplasia.

Area Of Science

  • Gynecologic Oncology
  • Cervical Pathology
  • Virology

Background

  • Atypical squamous cells, cannot exclude high-grade squamous intraepithelial neoplasia (ASC-H) is a cytologic finding requiring further investigation.
  • The role of high-risk human papillomavirus (HPV) testing in managing ASC-H cases requires clarification.

Purpose Of The Study

  • To investigate the correlation between high-risk HPV types and the presence of cervical intraepithelial neoplasia grade 2 or higher (CIN 2+) lesions in patients with ASC-H cytology.

Main Methods

  • Retrospective analysis of data from 5,271 patients who underwent colposcopy between 2003 and 2021.
  • Focus on 163 patients with ASC-H cytology, with 83 HPV-positive cases included.
  • Correlation analysis between HPV status (especially HPV 16) and final pathology results (CIN 2+).

Main Results

  • No significant correlation was found between patient age and CIN 2+ lesions (p=0.053).
  • HPV 16 positivity (alone or with other types) significantly increased the likelihood of CIN 2+ lesions in final pathology.
  • The probability of CIN 2+ lesions was 72.5% in HPV 16-positive ASC-H patients versus 48.1% in HPV 16-negative patients (p=0.033).

Conclusions

  • Current guidelines lack comprehensive definitions for HPV testing in ASC-H management.
  • Positive high-risk HPV results, especially HPV 16, in conjunction with ASC-H cytology, suggest a higher possibility of high-grade dysplasia.
  • HPV testing, particularly for HPV 16, is a valuable tool in assessing the risk of significant cervical pathology in ASC-H cases.

Keywords: