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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 29, 2026

Colorectal Cancer Cell Surface Protein Profiling Using an Antibody Microarray and Fluorescence Multiplexing
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CBD2: A functional biomarker database for colorectal cancer.

Xueli Zhang1,2,3,4, Min Li1,5, Siting Ye6,7

  • 1Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou China.

Imeta
|June 13, 2024
PubMed
Summary

The Colorectal Cancer Biomarker Database (CBD2) expands on previous work, now detailing 1569 new colorectal cancer biomarkers and non-biomarkers. It offers network analysis and aids in designing polypharmacological treatments.

Keywords:
biomarkercolorectal cancerdatabasenetwork analysis

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Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • Colorectal cancer (CRC) biomarker research is rapidly advancing, requiring updated resources.
  • The previous Colorectal Cancer Biomarker Database (CBD) cataloged 870 CRC biomarkers.
  • An integrated, updated repository is crucial for managing evolving biomarker information.

Purpose of the Study:

  • To develop CBD2, an enhanced database of colorectal cancer biomarkers.
  • To incorporate newly reported biomarkers from diverse biological sources and clinical applications.
  • To include information on non-biomarkers and provide advanced analytical tools.

Main Methods:

  • Curated collection and integration of newly reported CRC biomarkers (DNA, RNA, protein).
  • Inclusion of non-biomarker information.
  • Development of network analysis and multidrug/multitarget analysis functionalities.

Main Results:

  • CBD2 now contains information on 1569 newly reported CRC biomarkers.
  • The database includes data on non-biomarkers unsuitable for CRC.
  • New features enable network and pathway analysis, as well as polypharmacological treatment design.

Conclusions:

  • CBD2 serves as a comprehensive, updated resource for colorectal cancer biomarkers.
  • The database facilitates biomarker discovery, validation, and therapeutic strategy development.
  • CBD2 supports research into complex, multi-target treatments for colorectal cancer.