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Recurrent reactive hypoglycemia due to clozapine-induced glucose intolerance: A case report
Fumihiko Kawai1, Satsuki Watanabe1, Hirotaka Ebihara1
1Department of Psychiatry, Faculty of Medicine Saitama Medical University Saitama Japan.
Background:
Although diabetes is one of the most common side effects of clozapine, a medication for the treatment of schizophrenia, to the best of our knowledge no study exists on clozapine-induced glucose intolerance or hypoglycemia in patients with schizophrenia.
Case Presentation:
We report a case of schizophrenia with repeated reactive hypoglycemia due to abnormal glucose tolerance during clozapine treatment. During clozapine administration in patients with schizophrenia, it is necessary to monitor physical and psychiatric symptoms due to reactive hypoglycemia and hyperglycemia. If abnormal glucose tolerance is a concern, it should be promptly detected using blood or oral glucose tolerance tests.
Conclusion:
Early intervention for impaired glucose tolerance may prevent clozapine discontinuation due to diabetes or hyperglycemia.
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Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: