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Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Jun 24, 2025

Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples
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Faecal Immunochemical Test (FIT) Sensitivity; A Five Year Audit.

Eddie Cole1, Deepa Narayanan2, Ree Nee Tiam3

  • 1Blood Sciences Department, York and Scarborough Teaching Hospitals NHS Foundation Trust, York, United Kingdom.

British Journal of Biomedical Science
|June 13, 2024
PubMed
Summary
This summary is machine-generated.

The faecal immunochemical test (FIT) shows 92% sensitivity for colorectal cancer, but 8% of diagnosed patients had a negative result. The COVID-19 pandemic impacted diagnosis rates, highlighting potential false negatives in routine screening.

Keywords:
COVID-19FITSARS-CoV-2bowel cancercolorectal cancerfaecal immunochemical testintestinesensitivity

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Area of Science:

  • Gastroenterology
  • Oncology
  • Public Health

Background:

  • Colorectal cancer (CRC) presents a significant health burden in the UK.
  • Faecal immunochemical testing (FIT) is a primary screening tool for CRC, detecting faecal haemoglobin (Hb).
  • Understanding FIT's real-world performance is crucial for early CRC detection.

Purpose of the Study:

  • To evaluate the sensitivity of FIT in a routine clinical setting for colorectal cancer diagnosis.
  • To assess the impact of the COVID-19 pandemic on CRC diagnosis rates and FIT performance.
  • To identify reasons for false-negative FIT results in CRC patients.

Main Methods:

  • A retrospective audit of FIT results and CRC diagnoses in Hull and East Yorkshire (2018-2022).
  • Analysis of 56,202 FIT tests performed on symptomatic patients.
  • Correlation of FIT results with histologically confirmed CRC diagnoses.

Main Results:

  • 1,511 CRC cases were diagnosed; 450 had a preceding FIT within 12 months.
  • FIT sensitivity was 92.00%, with 36 (8.00%) potentially false-negative results (<10 μg/g).
  • Change in bowel habits was the most common symptom prompting FIT; COVID-19 impacted diagnosis numbers.

Conclusions:

  • FIT demonstrates high sensitivity (92%) in routine clinical practice for colorectal cancer.
  • A notable percentage (8%) of CRC patients had negative FIT results, indicating potential false negatives.
  • The study highlights the influence of external factors like the COVID-19 pandemic on CRC diagnosis and screening effectiveness.