Advancements in mercury detection using surface-enhanced Raman spectroscopy (SERS) and ion-imprinted polymers (IIPs):...

Mercury (Hg) contamination remains a major environmental concern primarily due to its presence at trace levels, making monitoring the concentration of Hg challenging. Sensitivity and selectivity are significant challenges in the development of mercury sensors. Surface-enhanced Raman spectroscopy (SERS) and ion-imprinted polymers (IIPs) are two distinct analytical methods developed and employed for mercury detection. In this review, we provide an overview of the key aspects of SERS and IIP methodologies, focusing on the recent advances in sensitivity and selectivity for mercury detection. By examining the critical parameters and challenges commonly encountered in this area of research, as reported in the literature, we present a set of recommendations. These recommendations cover solid and colloidal SERS substrates, appropriate Raman reporter/probe molecules, and customization of IIPs for mercury sensing and removal. Furthermore, we provide a perspective on the potential integration of SERS with IIPs to achieve enhanced sensitivity and selectivity in mercury detection. Our aim is to foster the establishment of a SERS-IIP hybrid method as a robust analytical tool for mercury detection across diverse fields.