[Non-pharmacological prevention of chronic kidney disease]

Area of Science:

• Nephrology
• Public Health
• Preventive Medicine

Background:

• Chronic kidney disease (CKD) presents a significant global health challenge, contributing to cardiovascular complications and reduced quality of life.
• Pharmacological interventions, including renin/angiotensin/aldosterone system blockers and SGLT2 inhibitors, are established CKD preventatives.
• Emerging therapies like mineralocorticoid receptor antagonists and GLP-1 receptor agonists are under investigation for nephroprotection.

Purpose of the Study:

• To comprehensively review and detail non-pharmacological strategies for the prevention and management of chronic kidney disease.
• To highlight the importance of lifestyle modifications in conjunction with medical treatments for CKD.

Main Methods:

• Review of current literature on non-medicinal approaches to CKD prevention.
• Synthesis of evidence regarding hygienic-dietary measures, including smoking cessation, physical activity, and specific dietary interventions.
• Discussion of the role of these non-pharmacological strategies in slowing CKD progression.

Main Results:

• Non-pharmacological measures, such as smoking avoidance, regular physical activity, and tailored dietetics, are crucial components of CKD prevention.
• These lifestyle interventions complement pharmacological treatments, offering a holistic approach to kidney health.
• Optimizing these factors can significantly contribute to slowing the progression of chronic kidney disease.

Conclusions:

• A multi-faceted approach combining pharmacological agents and non-pharmacological strategies is essential for effective CKD prevention and management.
• Emphasis on lifestyle modifications, including diet and exercise, is vital for public health initiatives targeting chronic kidney disease.
• Further research and clinical implementation of these non-medicinal approaches can improve patient outcomes and reduce the burden of CKD.