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Updated: Jun 24, 2025

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation
Published on: February 1, 2020
Traffic on the TLR expressway
Justin Taft1, Dusan Bogunovic1
1Department of Pediatrics and Center for Genetic Errors of Immunity, Columbia University Medical Center, New York, NY, USA.
Abstract:
Genetic variation in UNC93B1, a key component in TLR trafficking, can lead to autoinflammation caused by increased TLR activity. Analysis of seven patient variants combined with a comprehensive alanine screen revealed that different regions of UNC93B1 selectively regulate different TLRs (Rael et al. https://doi.org/10.1084/jem.20232005; David et al. https://doi.org/10.1084/jem.20232066).
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