Exploring the Thermal-Oxidative Stability of Azithromycin Using a Thermoactivated Sensor Based on Cerium Molybdate...

Area of Science:

• Analytical Chemistry
• Materials Science
• Pharmaceutical Science

Background:

• Chemical stability of azithromycin (AZM) is crucial for pharmaceutical efficacy.
• Thermo-oxidative conditions during transport and storage can compromise AZM integrity.
• Developing sensitive methods for assessing AZM stability is essential.

Purpose of the Study:

• To investigate the impact of thermo-oxidative conditions on azithromycin (AZM) chemical stability.
• To develop and validate an electrochemical sensor for monitoring AZM degradation.
• To establish the relationship between environmental factors and AZM half-life.

Main Methods:

• Electrochemical measurements using a composite electrode of thermoactivated cerium molybdate (Ce2(MoO4)3) and multi-walled carbon nanotubes (MWCNT).
• Exposure of AZM to varying temperatures (20-80 °C), UV radiation (257 nm), and air saturation.
• Analysis of AZM oxidation using phosphate buffer (pH 8) in a CH3OH/H2O mixture.

Main Results:

• A Ce2(MoO4)3/MWCNT composite electrode demonstrated high sensitivity (230 nM detection limit) and precision (RSD < 4.0%) for AZM detection.
• Thermal treatment of Ce2(MoO4)3 enhanced its electrocatalytic activity.
• MWCNT incorporation reduced charge-transfer resistance and amplified the signal.
• AZM half-life significantly decreased with increased temperature, UV exposure, and air saturation.

Conclusions:

• The developed electrochemical sensor effectively monitors AZM degradation under simulated storage and transport conditions.
• Increased temperature, UV radiation, and air saturation accelerate AZM decomposition.
• Continuous quality control of pharmaceuticals like azithromycin is vital to ensure patient health and drug efficacy.