Real time organ hypoperfusion detection using Indocyanine Green in a piglet model

Carolin Oppermann ¹, Niclas Dohrn ^2,3, Helin Yikilmaz Pardes ²

⁰Center for Surgical Science, Zealand University Hospital, Lykkebækvej 1, 4600, Køge, Denmark. caopp@regionsjaelland.dk.

Surgical Endoscopy +

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June 13, 2024

View abstract on PubMed

Summary

This study developed a new method for real-time organ perfusion monitoring during surgery using indocyanine green (ICG) to detect tissue hypoperfusion and aid surgical decisions.

Area Of Science

Surgical innovation
Medical imaging
Physiology

Background

Adequate tissue oxygenation is crucial for organ function.
Current methods for detecting tissue hypoperfusion during abdominal surgery are limited.
A novel perfusion monitoring technique is needed to assist surgical decision-making.

Purpose Of The Study

To develop and evaluate a new method for continuous organ perfusion monitoring.
To assess the ability of the method to detect real-time tissue hypoperfusion.
To aid surgeons in identifying and managing perfusion-related complications during abdominal procedures.

Main Methods

Experimental porcine model with thirteen subjects.
Organs studied included stomach, ascending colon, rectum, and spleen.
High-frequency, low-dose indocyanine green (ICG) injections were used for perfusion assessment.
Arterial occlusion was performed to induce controlled hypoperfusion.
Continuous organ perfusion monitoring was conducted throughout the experiment.

Main Results

Occlusion of peripheral arterial supply led to immediate decreases in organ oscillation signals in most cases.
Central arterial supply occlusion caused further signal reduction or complete loss of oscillation curves.
The ICG-based method effectively demonstrated changes in organ perfusion.

Conclusions

Continuous organ perfusion monitoring with high-frequency, low-dose ICG bolus injections is effective.
This technique can detect organ hypoperfusion in real-time during surgical procedures.
The method shows promise for improving intraoperative decision-making and patient outcomes.

Keywords:

Abdominal surgery Fluorescence Fluorescence-angiography Hypoperfusion Indocyanine Green Porcine study