Real time organ hypoperfusion detection using Indocyanine Green in a piglet model

Area of Science:

• Surgical innovation
• Medical imaging
• Physiology

Background:

• Adequate tissue oxygenation is crucial for organ function.
• Current methods for detecting tissue hypoperfusion during abdominal surgery are limited.
• A novel perfusion monitoring technique is needed to assist surgical decision-making.

Purpose of the Study:

• To develop and evaluate a new method for continuous organ perfusion monitoring.
• To assess the ability of the method to detect real-time tissue hypoperfusion.
• To aid surgeons in identifying and managing perfusion-related complications during abdominal procedures.

Main Methods:

• Experimental porcine model with thirteen subjects.
• Organs studied included stomach, ascending colon, rectum, and spleen.
• High-frequency, low-dose indocyanine green (ICG) injections were used for perfusion assessment.
• Arterial occlusion was performed to induce controlled hypoperfusion.
• Continuous organ perfusion monitoring was conducted throughout the experiment.

Main Results:

• Occlusion of peripheral arterial supply led to immediate decreases in organ oscillation signals in most cases.
• Central arterial supply occlusion caused further signal reduction or complete loss of oscillation curves.
• The ICG-based method effectively demonstrated changes in organ perfusion.

Conclusions:

• Continuous organ perfusion monitoring with high-frequency, low-dose ICG bolus injections is effective.
• This technique can detect organ hypoperfusion in real-time during surgical procedures.
• The method shows promise for improving intraoperative decision-making and patient outcomes.