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Updated: Jun 24, 2025

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Associations of cholecystectomy with the risk of gastroesophageal reflux disease: a Mendelian randomization study
Jin Qian1, Huawei Xu2, Jun Liu3
1Department of General Surgery, The First Affiliated Hospital of Wenzhou Medical University.
Background:
Cholecystectomy is the standard surgery for patients with gallbladder disease, but the impact of cholecystectomy on gastroesophageal reflux disease (GERD) is not clear.
Methods:
The authors obtained genetic variants associated with cholecystectomy at a genome-wide significant level ( P -value <5×10 -8 ) as instrumental variables (IVs) and performed Mendelian randomization to explore the relationship with GERD.
Results:
The Inverse Variance Weighted analysis (IVW) showed that the risk of GERD in patients after cholecystectomy increased (OR=2.19; 95% CI: 1.18-4.09). At the same time, the analysis results of weighted median (OR=2.30; 95% CI: 1.51-3.48) and weighted mode (OR=2.21; 95% CI: 1.42-3.45) were also consistent with the direction of the IVW analysis and were statistically significant ( P <0.05).
Conclusions:
This study shows that patients who have undergone cholecystectomy are a susceptible population of GERD.
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