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Indocyanine green clearance in critically ill patients
Surgery, Gynecology & Obstetrics
|December 1, 1979
Summary
The plasma disappearance rate of indocyanine green is a significant indicator of liver function in patients, distinguishing survivors from nonsurvivors. This liver function test showed a clear cut-off point, unlike other biochemical markers.
Area of Science:
- Hepatology
- Clinical Biochemistry
- Physiology
Background:
- Liver function is critical in patient outcomes.
- Assessing liver function requires reliable biochemical and physiological parameters.
- Traditional markers like transaminases may not fully capture functional capacity.
Purpose of the Study:
- To evaluate the utility of various liver function tests in predicting patient survival.
- To determine if specific biochemical and physiological parameters can differentiate between survivors and nonsurvivors.
- To investigate the diagnostic value of indocyanine green plasma disappearance rate.
Main Methods:
- Observation of 42 consecutive patients.
- Measurement of serum glutamic-oxalacetic transaminase, alkaline phosphatase, and bilirubin.
- Assessment of indocyanine green plasma disappearance rate.
- Comparison of parameters between survivor and nonsurvivor groups.
Main Results:
- No significant differences in serum glutamic-oxalacetic transaminase, alkaline phosphatase, or bilirubin levels between groups.
- A significant difference was observed in the plasma disappearance rate of indocyanine green.
- A cut-off value of 6% per minute for indocyanine green plasma disappearance rate distinguished survivors.
Conclusions:
- The plasma disappearance rate of indocyanine green is a sensitive indicator of liver function relevant to patient survival.
- Traditional liver enzyme tests showed limited value in differentiating outcomes in this cohort.
- Indocyanine green clearance offers a valuable physiological measure for prognostication in liver health.