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Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

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Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
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Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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  11. Compound Muscle Action Potential And Myosin-loss Pathology In Patients With Critical Illness Myopathy: Correlation And Prognostication

Compound Muscle Action Potential and Myosin-Loss Pathology in Patients With Critical Illness Myopathy: Correlation and Prognostication

Shahar Shelly1, Pannathat Soontrapa1, Nicolas N Madigan1

  • 1From the Department of Neurology (S.S., P.S., N.N.M., M.J.P., S.A.B., A.J.W., A.J.B., W.J.L., M.M., T.L.), Mayo Clinic, Rochester, MN; Department of Neurology (S.S.), Rambam Medical Center, Haifa, Israel; Division of Neurology (P.S.), Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Neurology (T.D.S.), University of Michigan, Ann Arbor; Department of Neurology (S.R.S.S.), University of Texas Health Sciences at Houston; Department of Neurology (P.P.), University of California, San Francisco; Department of Neurology (B.L.), Houston Methodist Hospital, TX; and Department of Physical Medicine and Rehabilitation (A.J.B.), Mayo Clinic, Rochester, MN.

Neurology
|June 13, 2024

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Immunolabelling Myofiber Degeneration in Muscle Biopsies
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View abstract on PubMed

Summary
This summary is machine-generated.

Prolonged compound muscle action potential (CMAP) duration is linked to myosin loss in critical illness myopathy (CIM). Longer CMAP duration predicts myosin loss, suggesting prognostic value for both in CIM outcomes.

Area of Science:

  • Neurology
  • Pathology
  • Critical Care Medicine

Background:

  • Critical illness myopathy (CIM) is characterized by prolonged compound muscle action potential (CMAP) duration and myosin loss.
  • The correlation and prognostic significance of these hallmarks in CIM have not been fully elucidated.
  • This study investigates the relationship between CMAP duration and myosin loss, and their impact on patient mortality.

Purpose of the Study:

  • To determine the correlation between prolonged CMAP duration and myosin loss in patients with CIM.
  • To evaluate the prognostic value of CMAP duration and myosin loss severity on mortality in CIM patients.

Main Methods:

  • Retrospective analysis of electrodiagnostic and muscle biopsy data from CIM patients (1986-2021).
  • Patients diagnosed with CIM based on prolonged CMAP durations and compatible needle EMG findings.

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  • Myosin/actin ratio analysis was performed on available muscle tissue; survival rates analyzed using Kaplan-Meier method.

    • Main Results:

    • Myosin loss was observed in 70% of CIM patients, with high-grade loss in 50% of these.
    • Patients with myosin loss exhibited significantly longer CMAP durations across multiple nerves.
    • While mortality rates were similar between groups, high-grade myosin loss showed a trend towards lower survival.

    Conclusions:

    • Prolonged CMAP duration is a strong predictor of myosin loss pathology in critical illness myopathy.
    • The extent of myosin loss shows a marginal correlation with mortality rates.
    • CMAP duration and myosin loss severity hold potential prognostic value for predicting outcomes in CIM.