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Updated: Jun 24, 2025

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Association between Lipoprotein(a) concentration and adverse cardiac events in patients with coronary artery disease:

Navaneeth Amin1, Tom Devasia1, Shobha Ullas Kamath2

  • 1Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Indian Heart Journal
|June 13, 2024
PubMed

Insights

Elevated lipoprotein (a) [Lp(a)] levels significantly increase the risk of adverse cardiac events, including heart attack and stroke, in patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Lipoprotein (a) [Lp(a)] is an emerging cardiovascular risk factor.
  • Elevated Lp(a) is linked to atherosclerosis and adverse cardiac outcomes.

Purpose of the Study:

  • To investigate the association between Lp(a) levels and adverse cardiac events in patients undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • Prospective study of 600 patients undergoing PCI for coronary artery disease.
  • Kaplan Meier analysis and Cox Regression modeling were used to assess risk.
  • Patients were stratified based on Lp(a) levels (≥30 mg/dL).

Main Results:

  • Patients with elevated Lp(a) (≥30 mg/dL) showed significantly higher rates of cardiac death, major adverse cardiac events, myocardial infarction, revascularization, and stroke.
  • Lp(a) ≥30 mg/dL was identified as a significant independent risk factor for adverse events (HR: 4.29; 95% CI: 2.58-7.12; p < 0.05).

Conclusions:

  • Elevated Lp(a) levels are a significant predictor of adverse cardiac events in patients with coronary artery disease undergoing PCI.
  • Monitoring and managing Lp(a) may be crucial for risk stratification and prevention in this patient population.

Keywords:
Adverse cardiac eventsCoronary artery diseaseLipoprotein(a)

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