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Updated: Jun 24, 2025

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
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Published on: May 24, 2020

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Renal Involvement in Thrombotic Thrombocytopenic Purpura: Is It Time to Challenge the Old Paradigm?

Lea Issa1, Nicolas Sandakly1, Georgio El Koubayati2

  • 1Internal Medicine, Faculty of Medicine, Lebanese University, Beirut, LBN.

Cureus
|June 14, 2024
PubMed

Thrombotic thrombocytopenic purpura (TTP) is clinical-pathological entity characterized by microangiopathic hemolytic anemia associated with end-organ dysfunction. Traditionally, TTP was characterized by the classic pentad of fever, thrombocytopenia, hemolytic anemia, renal impairment, and neurological manifestations. However, this classic pentad is only observed in 40% of cases. We herein describe the case of a female patient who presented with epigastric pain and vomiting and found to have TTP without the classic pentad but with rapidly progressive renal dysfunction.

Keywords:
acute kidney injuryacute kidney injury in ttphemolysisthrombotic thrombocytopenic thrombocytopeniattp pentad

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