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Updated: Jun 24, 2025

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
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Charting epimutation dynamics in human hematopoietic differentiation

Xiaohuan Qin1, Jiayi Lu1, Peng Wu1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Department of Stem Cell and Regenerative Medicine, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

Blood Science (Baltimore, Md.)
|June 14, 2024
PubMed
Summary

Epimutations, variations in DNA methylation, significantly impact blood cell development and diseases. Our study maps these epigenetic changes, revealing their crucial role in human hematopoiesis and offering new insights.

Keywords:
DNA methylationEpimutationHematopoietic differentiationHematopoietic stem cell

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