Distant organ metastasis patterns and prognosis of cervical adenocarcinoma: a population-based retrospective study

Suyu Li ¹, Wuyuan Pan ², Jianrong Song ²

⁰Department of Radiation Oncology, Fujian Maternity and Child Health Hospital, College of Clinical Medical for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.

Frontiers in Medicine +

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June 14, 2024

View abstract on PubMed

Summary

Distant organ metastasis in cervical adenocarcinoma most commonly affects single organs like the lungs. Treatments including surgery, radiotherapy, and chemotherapy may improve survival for these patients.

Area Of Science

Oncology
Gynecologic Oncology
Cancer Metastasis Research

Background

Cervical adenocarcinoma is a frequent histological subtype of cervical cancer.
Prognosis for cervical adenocarcinoma with distant organ metastases is not well-defined.
Understanding metastasis patterns is crucial for improving patient outcomes.

Purpose Of The Study

To investigate the patterns of distant organ metastasis in cervical adenocarcinoma.
To analyze the prognostic impact of distant organ metastasis in cervical adenocarcinoma.
To evaluate the survival benefits of different treatment modalities for metastatic cervical adenocarcinoma.

Main Methods

Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (2010-2019).
Employed Cox regression, Kaplan-Meier, and log-rank analyses for statistical evaluation.
Identified patterns and prognostic factors of distant organ metastasis.

Main Results

Cervical adenocarcinoma predominantly metastasizes to single organs (73.3%), with lungs being the most common site, followed by liver and bone.
Bone metastasis showed a median survival of 12 months, slightly longer than other metastatic sites.
Distant metastasis, advanced age, positive lymph nodes, higher AJCC stages, larger tumor size, and higher tumor grade were associated with poor prognosis (p < 0.001).
Surgical intervention, radiotherapy, and chemotherapy demonstrated potential benefits for patients with distant metastases.

Conclusions

Distant organ metastasis is an independent negative prognostic factor for cervical adenocarcinoma.
Treatment modalities including surgery, radiotherapy, and chemotherapy can offer survival advantages to patients with distant organ metastases.

Keywords:

SEER database cervical adenocarcinoma metastasis prognosis survival

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