Research hotspots and emerging trends of mesenchymal stem cells in cardiovascular diseases: a bibliometric-based
Zhihang Jiang1, Jiajing Yu1, Houle Zhou1
1Department of Anatomy, School of Chinese Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Insights
Mesenchymal stem cells (MSCs) show promise for cardiovascular diseases (CVDs). This bibliometric analysis reveals research trends, hotspots like exosomes and myocardial infarction, and future directions for MSCs in CVDs.
Area of Science:
- Biomedical research
- Regenerative medicine
- Cardiovascular science
Background:
- Mesenchymal stem cells (MSCs) hold significant potential for treating cardiovascular diseases (CVDs).
- Limited bibliometric analyses exist for MSCs in the context of CVDs.
- This study provides a comprehensive bibliometric overview of MSC research in CVDs.
Purpose of the Study:
- To analyze the global research landscape of MSCs in CVDs.
- To identify key countries, institutions, authors, and journals.
- To elucidate research hotspots, evolution paths, and future trends.
Main Methods:
- Bibliometric analysis of 4,852 publications from the Web of Science Core Collection (up to August 31, 2023).
- Utilized CiteSpace and VOSviewer for data analysis and knowledge mapping.
- Keywords and reference cluster analysis to identify research themes.
Main Results:
- China leads in publication volume, though with noted quality concerns.
- Significant research interest in exosomes, extracellular vesicles, and microvesicles.
- Myocardial infarction, therapy, and transplantation are prominent research keywords, with a long-term focus on extracellular vesicles.
Conclusions:
- MSCs in CVDs represent a dynamic research area with substantial potential.
- This analysis offers valuable insights into current progress, hotspots, and future research directions.
- The findings can guide future research strategies in MSC-based cardiovascular therapies.
Background:
Mesenchymal stem cells (MSCs) have important research value and broad application prospects in cardiovascular diseases (CVDs). However, few bibliometric analyses on MSCs in cardiovascular diseases are available. This study aims to provide a thorough review of the cooperation and influence of countries, institutions, authors, and journals in the field of MSCs in cardiovascular diseases, with the provision of discoveries in the latest progress, evolution paths, frontier research hotspots, and future research trends in the regarding field.
Methods:
The articles related to MSCs in cardiovascular diseases were retrieved from the Web of Science. The bibliometric study was performed by CiteSpace and VOSviewer, and the knowledge map was generated based on data obtained from retrieved articles.
Results:
In our study, a total of 4,852 publications launched before August 31, 2023 were accessed through the Web of Science Core Collection (WoSCC) database via our searching strategy. Significant fluctuations in global publications were observed in the field of MSCs in CVDs. China emerged as the nation with the largest number of publications, yet a shortage of high-quality articles was noted. The interplay among countries, institutions, journals and authors is visually represented in the enclosed figures. Importantly, current research trends and hotspots are elucidated. Cluster analysis on references has highlighted the considerable interest in exosomes, extracellular vesicles, and microvesicles. Besides, keywords analysis revealed a strong emphasis on myocardial infarction, therapy, and transplantation. Treatment methods-related keywords were prominent, while keywords associated with extracellular vesicles gathered significant attention from the long-term perspective.
Conclusion:
MSCs in CVDs have become a topic of active research interest, showcasing its latent value and potential. By summarizing the latest progress, identifying the research hotspots, and discussing the future trends in the advancement of MSCs in CVDs, we aim to offer valuable insights for considering research prospects.
