Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

  1. Home
  3. The Role Of Donor Hypertension And Angiotensin Ii In The Occurrence Of Early Pancreas Allograft Thrombosis.
  1. Home
  3. The Role Of Donor Hypertension And Angiotensin Ii In The Occurrence Of Early Pancreas Allograft Thrombosis.

Related Experiment Video

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique
13:19

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique

Published on: December 16, 2017

11.0K

The role of donor hypertension and angiotensin II in the occurrence of early pancreas allograft thrombosis.

Christophe Masset1,2, Julien Branchereau1,2, Fanny Buron3

  • 1Institut de Transplantation-Urologie-Néphrologie (ITUN), Nantes University Hospital, Nantes, France.

Frontiers in Immunology
|June 14, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Donor hypertension significantly increases early pancreas transplant failure risk. Renin-angiotensin-aldosterone system (RAAS) blockers may mitigate this risk, improving graft survival.

Keywords:
allograft thrombosisbody mass index (BMI)high blood pressureimmunothrombosispancreas transplantationpre-procurement pancreas suitability score

More Related Videos

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice
06:41

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Published on: May 10, 2021

3.7K
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

27.4K

Related Experiment Videos

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique
13:19

Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique

Published on: December 16, 2017

11.0K
Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice
06:41

Minimizing Post-Infusion Portal Vein Bleeding during Intrahepatic Islet Transplantation in Mice

Published on: May 10, 2021

3.7K
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
10:43

Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice

Published on: October 31, 2007

27.4K

Area of Science:

  • Transplantation immunology
  • Nephrology
  • Cardiovascular medicine

Background:

  • Pancreas allograft loss impacts early postoperative outcomes.
  • Graft thrombosis is a major cause of early pancreas graft failure.
  • Identifying risk factors for pancreas graft failure is crucial.

Purpose of the Study:

  • To investigate donor hypertension as a risk factor for early pancreas allograft failure.
  • To analyze the impact of donor hypertension on long-term pancreas, kidney, and patient survival.
  • To explore the role of the Renin Angiotensin Aldosterone System (RAAS) in pancreas graft outcomes.

Main Methods:

  • Multicenter study of 899 pancreas transplant recipients (2000-2018).
  • Analysis of early graft failure, long-term pancreas, kidney, and patient survival.
  • Multivariate cause-specific Cox model adjusted for donor, recipient, and perioperative variables.

    • Main Results:

    • Donor hypertension (6.7%) and high BMI were independently associated with increased early pancreas failure (HR=2.57, HR=1.11).
    • Donor hypertension significantly impacted long-term pancreas survival (HR=1.88) but not after postoperative day 30.
    • Pancreas survival was significantly lower in recipients of hypertensive donors without RAAS blockers (14% vs 50%).

    Conclusions:

    • Donor hypertension is a significant independent risk factor for early pancreas graft failure.
    • The Renin Angiotensin Aldosterone System (RAAS) appears involved in immediate graft failure.
    • RAAS blockers may improve outcomes for pancreas transplants from hypertensive donors.