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Updated: Jun 24, 2025
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
725
Urinary eosinophil-derived neurotoxin is associated with reduced lung function in pediatric asthma
Jimmy Omony1,2, Clemens Thölken3, Azam Salimi4
1Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.
Summary
Urinary eosinophil-derived neurotoxin (uEDN) can non-invasively monitor pediatric asthma activity. Higher uEDN levels correlate with atopy and reduced lung function, suggesting its utility as a clinical biomarker.
Area of Science:
- Biochemistry
- Immunology
- Pediatric Pulmonology
Background:
- Eosinophil-derived neurotoxin (EDN) is a key biomarker for eosinophilic activation.
- Urinary EDN (uEDN) offers a potential non-invasive method for monitoring asthma.
- Clinical guidelines for uEDN use in asthma management are currently lacking.
Purpose of the Study:
- To evaluate the potential of uEDN as a marker for disease activity in pediatric asthma.
- To assess the correlation of uEDN levels with atopy and lung function in children.
- To determine the utility of uEDN in phenotyping pediatric asthma.
Main Methods:
- Analysis of urine samples from 371 children (preschool wheezers, asthmatics, healthy controls) from the German ALLIANCE study.
- Measurement of creatinine-adjusted urinary EDN (uEDN/uCr) using the ImmunoCAP™ EDN Assay.
- Statistical analysis including correlations, association tests, and regression modeling.
Main Results:
- Higher uEDN/uCr levels were observed in atopic versus non-atopic children and correlated with allergen-specific IgE.
- uEDN/uCr levels were significantly higher in children with the T2-high asthma phenotype.
- uEDN/uCr showed a significant correlation with reduced lung function (FEV1 and FEV1/FVC) in asthmatic children.
Conclusions:
- Urinary EDN (uEDN/uCr) shows promise as a non-invasive biomarker for assessing clinical features like lung function in pediatric asthma.
- uEDN/uCr can be easily measured using robust, widely available diagnostic immunoassays.
- This biomarker aids in understanding and managing pediatric asthma through objective measurements.
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